How long can you take indomethacin?

Can indomethacin be used long term?

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs may increase your risk of heart attack, heart failure, or stroke. This risk may be higher if you’re taking it long term, at high doses, or if you already have heart problems or risk factors for heart disease, such as high blood pressure.

Can I take indomethacin every day?

Adults—25 milligrams (mg) two or three times a day. Your doctor may increase your dose by 25 or 50 mg per day, as needed. However, the total dose is usually not more than 200 mg per day. Children 15 years of age and older—Dose is based on body weight and must be determined by your doctor.

How long does indomethacin stay in your system?

The mean half- life of indomethacin is estimated to be about 4.5 hours. With a typical therapeutic regimen of 25 or 50 mg t.i.d., the steady-state plasma concentrations of indomethacin are an average 1.4 times those following the first dose.

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How does indomethacin make you feel?

Upset stomach, heartburn, headache, drowsiness, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Is indomethacin hard on your liver?

Drug induced liver injury from indomethacin is usually mild-to-moderate in severity and transient, but can progress to acute liver failure and death. In large case series, indomethacin is rarely mentioned as a cause of acute liver failure. Rechallenge may lead to recurrence and should be avoided.

Is indomethacin stronger than ibuprofen?

Indomethacin is a much stronger anti-inflammatory medication than ibuprofen. So, 50 mg. of indomethacin is much stronger than 600 mg.

Is indomethacin a good painkiller?

Indomethacin is used to relieve pain, swelling, and joint stiffness caused by arthritis, gout, bursitis, and tendonitis. It is also used to relieve pain from various other conditions. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).

Who should not take indomethacin?

stomach or intestinal ulcer. ulcerative colitis, an inflammatory condition of the intestines. liver problems. bleeding of the stomach or intestines.

What can you not take with indomethacin?

What drugs and food should I avoid while taking Indomethacin (Indocin)? Avoid alcohol. Heavy drinking can increase your risk of stomach bleeding. Avoid taking aspirin unless your doctor tells you to.

Can indomethacin cause heart attack?

Indomethacin can increase your risk of fatal heart attack or stroke, even if you don’t have any risk factors. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Indomethacin may also cause stomach or intestinal bleeding, which can be fatal.

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Can indomethacin make you sleepy?

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising.

What are the side effects of indomethacin 50 mg?

Indomethacin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache.
  • dizziness.
  • vomiting.
  • diarrhea.
  • constipation.
  • irritation of the rectum.
  • constant feeling of the need to empty the bowel.
  • ringing in the ears.

Does indomethacin cause anxiety?

Results: Thirty-two patients experienced a psychiatric reaction after receiving indomethacin for postpartum pain. The symptoms were often severe and included dizziness, anxiety, fear, agitation, affective lability, depersonalization, paranoia, and hallucinations.

Is indomethacin good for back pain?

A short-term double-blind sequential trial of indomethacin against placebo in the treatment of low back pain, with and without nerve root pain such as sciatica, showed that indomethacin was significantly more effective than placebo in the group with nerve root pain.

What drugs interact with indomethacin?

Some products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as valsartan, losartan), cidofovir, corticosteroids (such as prednisone), lithium, methotrexate, “water pills” (diuretics such as furosemide).

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